Due to the Messerschmitt Bf-109's versatility and time in service with both the Luftwaffe and other foreign air forces, numerous variants were produced over the eight years of service with the Luftwaffe and even more were produced by its foreign users.

As the DB 601E was not yet available in numbers, the pre-production F-0 (the only F variant to have a rectangular supercharger intake) and the first production series F-1/F-2 received the 1,175 PS (1,159 hp, 864 kW) DB 601N engine driving a VDM 9-11207 propeller. The F-0/F-1 and F-2 only differed in their armament; the F-1 being fitted with one 20 mm MG FF/M Motorkanone firing through the engine hub, with 60 rounds. The F-1 first saw action in the Battle of Britain in October 1940 with JG 51. The most experienced fighter aces like Werner Mölders were the first ones to fly the first Bf 109 F-1s in combat in October 1940. A total of 208 F-1s were built between August 1940 and February 1941 by Messerschmitt Regensburg and the Wiener Neustädter Flugzeugwerke.

The F-2 introduced the 15 mm Mauser MG 151 cannon with 200 rounds. The Motorkanone was supplemented by two synchronized 7.92 mm (.312 in) MG 17 machine guns mounted under the engine cowl, with 500 rpg. As the harder-hitting 20 mm version of the same gun become available, a number of F-2s were retrofitted with it in the field. About 1,380 F-2s were built between October 1940 and August 1941 by AGO, Arado, Erla, Messerschmitt Regensburg and WNF. No tropicalized version was built, although individual F-2s were retrofitted with sand filters in the field. The maximum speed of the F-1 and F-2 was 615 km/h (382 mph) at rated altitude.

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