The Eagle's initial versions were designated F-15A for the single-seat configuration and F-15B (originally TF-15A, but this designation was quickly deprecated, as the F-15B is fully combat-capable) for the twin-seat. These versions would be powered by new Pratt & Whitney F100 engines to achieve a combat thrust-to-weight ratio in excess of 1 to 1. A proposed 25 mm Ford-Philco GAU-7 cannon with caseless ammunition was dropped in favor of the standard M61 Vulcan gun due to development problems. The F-15 retained conformal carriage of four Sparrow missiles like the Phantom. The fixed wing was put onto a flat, wide fuselage that also provided an effective lifting surface. Some questioned if the zoom performance of the F-15 with Sparrow missiles was enough to deal with the new threat of the high-flying MiG-25 "Foxbat", but its capability was eventually demonstrated in combat.

The first F-15A flight was made in July 1972 with the first flight of the two-seat F-15B (formerly TF-15A) following in July 1973.

The F-15 has a "look-down/shoot-down" radar that can distinguish low-flying moving targets from ground clutter. The F-15 would use computer technology with new controls and displays to lower pilot workload and require only one pilot to save weight. Unlike the F-14 or F-4, the F-15 has only a single canopy frame with clear vision forward. The USAF introduced the F-15 as "the first dedicated USAF air superiority fighter since the F-86 Sabre."

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