The Mk 22 was identical to the Mk 21 in all respects except for the cut-back rear fuselage, with the tear-drop canopy, and a more powerful 24 volt electrical system in place of the 12 volt system of all earlier Spitfires. Most of the Mk 22s were built with enlarged tail surfaces, similar to those of the Supermarine Spiteful. A total of 287 Mk 22s were built: 260 at Castle Bromwich and 27 by Supermarine at South Marston.

The Mk 22 was used by only one regular RAF unit, 73 Squadron based on Malta. However 12 squadrons of the Royal Auxiliary Air Force used the variant and continued to do so until March 1951. The Mk 22 was also used at Flying refresher schools. In May 1955 the remaining F.22s were declared obsolete for all RAF purposes and many were sold back to Vickers-Armstrongs for refurbishment and were then sold to the Southern Rhodesian, Egyptian and Syrian Air Forces.

The final Spitfire variant, the Mk 24, was similar to the Mk 22 except that it had an increased fuel capacity over its predecessors, with two fuel tanks of 33 gal each installed in the rear fuselage. There were also zero-point fittings for rocket projectiles under the wings. All had the larger "Spiteful" tail units: modifications were also made to the trim tab gearings in order to perfect the F Mk 24's handling characteristics. The F Mk 24 achieved a maximum speed of 454 mph (731 km/h), and could reach an altitude of 30,000 ft (9,100 m) in eight minutes, putting it on a par with the most advanced piston-engined fighters of the era.

Although designed primarily as a fighter-interceptor aircraft, the Spitfire proved its versatility in several different roles. In fighter configuration the F Mk 24's armament consisted of 4 × short-barrelled 20 mm Hispano cannon – operational experience had proved that the hitting power of these larger weapons was necessary to overcome the thicker armoured plating encountered on enemy aircraft as the war progressed. The aircraft also served successfully in the fighter-bomber role, being capable of carrying 1 × 500 lb (230 kg) and 2 × 250 lb (110 kg) bombs, with rocket-projectile launch rails fitted as standard. Late production aircraft were built with the lighter, short-barrelled, electrically fired Mark V Hispano cannon.

A total of 81 Mk 24s were completed, 27 of which were conversions from Mk 22s. The last Mk 24 to be built was delivered in February 1948. They were used by only one RAF squadron, 80 Squadron, until 1952. Some of the squadron's aircraft went to the Hong Kong Auxiliary Air Force where they were operated until 1955.

Introduced into service in 1946, the F Mk 24 differed greatly from the original Spitfire Mk I in many respects and was twice as heavy, more than twice as powerful and showed an increase in climb rate of 80% over that of the prototype, 'K5054'. These remarkable increases in performance arose chiefly from the introduction of the Rolls-Royce Griffon engine in place of the famous Merlin of earlier variants. Rated at 2,050 hp (1,530 kW), the 12-cylinder Vee liquid cooled Griffon 61 engine featured a two-stage supercharger, giving the Spitfire the exceptional performance at high altitude that had been sometimes lacking in early marks.

Drie uitvoeringen mogelijk;

No.80 Squadron, RAF, Kai Tak, Hong Kong, 1951.
No.73 Squadron, RAF, Ta Mali, Malta, 1948.
No.603(City of Edinburgh)Squadron, Royal Auxiliary Air Force, turnhouse, UK, 1951.